Open AccessPrognosis in systemic lupus erythematosus
Author(s) -
Reveille John D.,
Bartolucci Alfred,
Alarcón Graciela S.
Publication year - 1990
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780330105
Subject(s) - medicine , multivariate analysis , survivorship curve , univariate analysis , risk factor , systemic lupus erythematosus , lupus erythematosus , immunology , disease , antibody , cancer
Abstract To assess the impact of demographic and clinical factors on prognosis in patients with systemic lupus erythematosus (SLE), we examined survivorship by life‐table analysis in 389 patients. There were approximately equal numbers of Caucasian patients and American black patients in this study group. On both univariate and multivariate analyses, we found that both American black race and increasing age at SLE onset independently worsened the probability of survival. Of all the clinical factors we analyzed, thrombocytopenia emerged as the only independent risk factor for a worse prognosis in SLE. In all clinical and demographic groups considered, the leading cause of death was infection.