Open AccessA retrospective study of antibodies against basement membrane antigens (type iv collagen and laminin) in patients with primary and secondary raynaud's phenomenon
Author(s) -
Gabrielli Armando,
Montroni Maria,
Rupoli Serena,
Caniglia Maria Luisa,
Delustro Frank,
Danieli Giovanni
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780311114
Subject(s) - medicine , antibody , laminin , antigen , basement membrane , serology , scleroderma (fungus) , type iv collagen , immunology , pathology , chemistry , cell , biochemistry , inoculation
Antibodies against type IV collagen were detected in the sera of 21% of patients with primary Raynaud's phenomenon (PRP) and 68% of patients with systemic sclerosis. Sera from 25% of the PRP patients and 48% of systemic sclerosis patients displayed antibodies to laminin. Eighty percent of the patients with PRP and antibodies to basement membrane antigens developed additional serologic or clinical manifestations, whereas only 16% of patients with PRP and no anti—basement membrane antibodies developed such manifestations.