Open AccessNonlinkage of the t cell receptor α, β, and γ genes to systemic lupus erythematosus in multiplex families
Author(s) -
Wong David W.,
Bentwich Zvi,
MartinezTarquino Carlos,
Seidman J. G.,
Duby Allan D.,
Quertermous Thomas,
Schur Peter H.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780311105
Subject(s) - t cell receptor , restriction fragment length polymorphism , gene , biology , southern blot , genetics , restriction fragment , immunology , lupus erythematosus , pathogenesis , immunogenetics , microbiology and biotechnology , t cell , polymerase chain reaction , antibody , immune system
To test the possibility that T cell antigen receptor (TcR) genes are linked to the genes involved in the pathogenesis of systemic lupus erythematosus (SLE), genomic DNA restriction fragment length polymorphisms were studied, using the Southern blot technique, in 5 families with multiple members with SLE, 14 unrelated SLE patients, and 14 normal controls. Polymorphic patterns were detected with probes for all 3 TcR chains, but there was no significant difference in the distribution of the restriction fragment length polymorphism pattern among the patients, the relatives, and the controls. Furthermore, in the families with at least 2 individuals with the disease, each of the 3 TcR chain genes did not cosegregate with the disease. We conclude that TcRα, β, γ chain genes are not likely to be linked to genes related to SLE.