Open AccessSuppression of streptococcal cell wall–induced arthritis by a potent protease inhibitor, bis(5‐amidino‐2‐benzimidazolyl)methane
Author(s) -
Dieter Geratz J.,
Pryzwansky Katherine B.,
Schwab John H.,
Anderle Sonia K.,
Tidwell Richard R.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780310911
Subject(s) - arthritis , synovitis , proteases , hyperplasia , protease inhibitor (pharmacology) , trypsin , trypsin inhibitor , inflammation , protease , immunology , chemistry , medicine , virus , pathology , enzyme , biochemistry , antiretroviral therapy , viral load
Bis(5‐amidino‐2‐benzimidazolyl)methane, a powerful synthetic trypsin inhibitor, proved to be highly effective in suppressing the arthritis induced by streptococcal cell wall fragments in Lewis rats. It reduced not only the degree of synovitis, osteitis, and hematopoietic hyperplasia in the distal extremities, but also the degree of associated granulomatous inflammation in the liver. The results suggest that trypsin‐like proteases play an important role in this arthritis model and that inhibitors may be useful in the treatment of similar arthritic conditions in humans.