Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum | Zendy

Saxne T. | Zendy; Palladino M. A. | Zendy; Heinegãrd D. | Zendy; Talal N. | Zendy; Wollheim F. A. | Zendy

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Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

Author(s) -

Saxne T.,

Palladino M. A.,

Heinegãrd D.,

Talal N.,

Wollheim F. A.

Publication year - 1988

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780310816

Subject(s) - synovial fluid , rheumatoid arthritis , tumor necrosis factor alpha , medicine , erythrocyte sedimentation rate , necrosis , arthritis , rheumatoid factor , tumor necrosis factor α , immunology , reactive arthritis , pathology , osteoarthritis , alternative medicine

Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis patients was positive. Gamma‐inter‐feron was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids. RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.

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