Open AccessDetection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum
Author(s) -
Saxne T.,
Palladino M. A.,
Heinegãrd D.,
Talal N.,
Wollheim F. A.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780310816
Subject(s) - synovial fluid , rheumatoid arthritis , medicine , tumor necrosis factor alpha , erythrocyte sedimentation rate , necrosis , arthritis , tumor necrosis factor α , rheumatoid factor , immunology , pathology , reactive arthritis , osteoarthritis , alternative medicine
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis patients was positive. Gamma‐inter‐feron was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids. RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.