Open AccessIdentification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis
Author(s) -
Fife Rose S.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780310414
Subject(s) - synovial fluid , osteoarthritis , cartilage , hyaline cartilage , fibrocartilage , proteoglycan , pathology , glycoprotein , medicine , cartilage oligomeric matrix protein , matrix (chemical analysis) , anatomy , chemistry , articular cartilage , biochemistry , alternative medicine , chromatography
Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consists of disulfide‐bonded subunits, each with an apparent molecular weight of 116, 000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.