Open AccessAntibodies to types i, ii, ix, and xi collagen in the serum of patients with rheumatic diseases
Author(s) -
Charríre Guyĺne,
Hartmann Daniel J.,
Vig Eric,
Ronzíre MarieClaire,
Herbage Daniel,
Ville G´rard
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780310303
Subject(s) - rheumatoid arthritis , medicine , antibody , type ii collagen , osteoarthritis , radioimmunoassay , osteoporosis , arthritis , immunology , type i collagen , collagen disease , disease , gastroenterology , pathology , alternative medicine
Antibodies to native types I, II, IX, and XI collagen were measured, using a 125 I‐solid‐phase radio‐immunoassay, in serum from 104 patients with rheumatic diseases (rheumatoid arthritis, osteoporosis, Paget's disease, or osteoarthritis). In all disease groups, antibodies to type II collagen occurred with greater frequency than antibodies to type I collagen (11–35% versus 5–23%). Antibodies to type XI collagen were the most frequent: They were present in ˜50% of the patients in the rheumatoid arthritis, Paget's disease, and osteoporosis groups. Antibodies to type IX collagen were found at a high frequency in the rheumatoid arthritis group only (44%). Analysis of the clinical data suggested that the presence of antibodies to collagen was associated with disease that was less severe or of shorter duration.