Open AccessIncidence of anti‐human ig with restricted specificity in japanese, kuwaiti, and swedish patients with rheumatoid arthritis
Author(s) -
Grubb R.,
Matsumoto H.,
Sattar M. A.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780310109
Subject(s) - allotype , rheumatoid arthritis , immunology , medicine , incidence (geometry) , antibody , mathematics , geometry
Assuming that anti‐allotypic anti‐Ig in rheumatoid arthritis is stimulated by the individual's allotype, it would be reasonable to expect a higher incidence of anti‐G1m(a) in individuals carrying G1m(a). There is marked divergence among various populations in allotype frequencies. G1m(a) allotype and the prevalence of anti‐Ig reactive with G1m(a) Ig were determined in 18 Kuwaiti, 23 Japanese, and 41 Swedish rheumatoid arthritis patients. An inverse relationship was observed between the frequency distribution of allotype G1m(a) and anti‐allotype; thus, the stimulus for the anti‐allotype is not the patient's own allotype.