Open AccessExperimental arthritis induced by polysaccharide macromolecules
Author(s) -
Aaron Roy K.,
Sledge Clement B.,
Shortkroff Sonya
Publication year - 1987
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780300611
Subject(s) - inflammation , polysaccharide , macromolecule , arthritis , in vivo , chemistry , carrageenan , immunology , medicine , biology , biochemistry , microbiology and biotechnology
Several polysaccharide macromolecules are capable of inducing synovial inflammation. Characteristics of polysaccharides that have this capacity were studied in an in vivo rabbit model. The ability to induce synovial inflammation was positively correlated with the presence of sulfate and with high molecular weight. Understanding the characteristics of molecules that produce inflammation may help in the investigation to determine what mechanisms initiate the inflammatory response.