Open AccessHuman synovial fibroblasts produce urokinase‐type plasminogen activator
Author(s) -
Medcalf Robert L.,
Hamilton John A.
Publication year - 1986
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780291113
Subject(s) - plasminogen activator , urokinase , chemistry , activator (genetics) , retinoic acid , monocyte , microbiology and biotechnology , immunology , biochemistry , endocrinology , biology , medicine , receptor , gene
The plasminogen activator produced by cultured human synovial fibroblasts was investigated both biochemically and immunologically. Stimulated either by all‐trans‐retinoic acid or by monocyte‐conditioned medium, these fibroblasts elaborated a plasminogen activator with electrophoretic mobility similar to that of urokinase ( M r = 52 kilodaltons), and which also had immunologic cross‐reactivity with urokinase. The plasminogen activator found in rheumatoid synovial fluids has been shown to be of the urokinase type. The findings reported here are consistent with the notion that synovial fibroblasts are a source of this proteinase.