CHARACTERIZATION OF RABBIT GENES FOR SYNOVIAL CELL COLLAGENASE | Zendy

Fini M. Elizabeth | Zendy; Gross Robert H. | Zendy; Brinckerhoff Constance E. | Zendy

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CHARACTERIZATION OF RABBIT GENES FOR SYNOVIAL CELL COLLAGENASE

Author(s) -

Fini M. Elizabeth,

Gross Robert H.,

Brinckerhoff Constance E.

Publication year - 1986

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780291102

Subject(s) - collagenase , gene , microbiology and biotechnology , biology , synovial membrane , gene expression , microbial collagenase , cell , in situ hybridization , genome , rheumatoid arthritis , genetics , immunology , biochemistry , enzyme

To provide tools for understanding collagenase gene expression in rheumatoid arthritis, we have isolated and characterized genomic clones for rabbit synovial cell collagenase. These clones represent 2 types of collagenase gene, at least 1 of which is transcribed in synovial fibroblasts. By examining the rabbit genome in situ, we provide evidence that there are only 2 different synovial cell collagenase genes found in a haploid genome. Amplification of these genes is not a mechanism for collagenase messenger RNA induction by phorbol esters.

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