Open AccessUrinary neopterin reflects clinical activity in patients with rheumatoid arthritis
Author(s) -
Reibnegger Gilbert,
Egg Dietmar,
Fuchs Dietmar,
Günther Robert,
Hausen Arno,
Werner Ernst R.,
Wachter Helmut
Publication year - 1986
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780290902
Subject(s) - neopterin , rheumatoid arthritis , urinary system , medicine , osteoarthritis , arthritis , immunology , gastroenterology , pathology , alternative medicine
Neopterin is a marker for activation of cellular immunity. Urinary neopterin levels were measured in 106 patients with rheumatoid arthritis (RA) and in 45 patients with osteoarthritis. Levels were significantly higher in RA patients than in osteoarthritis patients and were strongly dependent on stage and activity of RA. Correlations with other laboratory parameters were weak. Multivariate analysis demonstrated that urinary neopterin levels reflected clinical activity better than did other laboratory findings. Thus, urinary neopterin determination might be useful in monitoring RA patients.