Open AccessFurther evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus
Author(s) -
Baer Alan N.,
Woosley Raymond L.,
Pincus Theodore
Publication year - 1986
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780290408
Subject(s) - medicine , phenotype , immunology , lupus erythematosus , disease , clinical phenotype , systemic lupus erythematosus , age of onset , systemic disease , systemic lupus , immunopathology , antibody , biology , genetics , gene
An association between host acetylator phenotype and idiopathic systemic lupus erythematosus (SLE) has been sought for over a decade, without a definitive result. We have observed that the frequency of the slow acetylator phenotype was similar in 64 patients with idiopathic SLE (38%), 60 healthy volunteers (50%), and 52 non‐SLE medical service patients (44%). The slow acetylator phenotype was not more frequent among subgroups of the SLE patients defined by demographic features or specific manifestations of disease. Our results, as well as a majority of previously published results, do not provide evidence for an association between acetylator phenotype and idiopathic SLE.