Open AccessHistamine stimulates prostaglandin E production by rheumatoid synovial cells and human articular chondrocytes in culture
Author(s) -
Taylor David J.,
Yoffe Joan R.,
Brown Diane M.,
Woolley David E.
Publication year - 1986
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780290202
Subject(s) - histamine , rheumatoid arthritis , medicine , prostaglandin , synovial membrane , prostaglandin e2 , immunology , chemistry
Histamine stimulates prostaglandin E (PGE) production by cultures of adherent rheumatoid synovial cells and human articular chondrocytes. When subcultured synovial fibroblasts or human articular chondrocytes were “primed” by preincubation with conditioned media from primary adherent rheumatoid synovial cell cultures (synovial factor), each produced even higher PGE levels upon histamine exposure. This histamine stimulation was prevented by histamine H 1 , but not H 2 , antagonists and was more marked if serum was absent from the culture media. Thus, histamine‐induced PGE production by these cells is mediated via H 1 receptor activation and subsequent arachidonic acid liberation.