Open AccessInspiratory muscle dysfunction and unexplained dyspnea in systemic lupus erythematosus
Author(s) -
Jacobelli Sergio,
Moreno Rodrigo,
Massardo Loreto,
Rivero Santiago,
Lisboa Carmen
Publication year - 1985
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780280709
Subject(s) - medicine , lung volumes , cardiology , pathogenesis , systemic disease , diffusing capacity , lupus erythematosus , lung , compliance (psychology) , gastroenterology , immunopathology , immunology , antibody , lung function , social psychology , psychology
The role of inspiratory muscle dysfunction in lung volume restriction and unexplained dyspnea was studied in 16 consecutive patients with systemic lupus erythematosus. Maximal mouth inspiratory pressure (P IM ) and maximal transdiaphragmatic pressure (Pdi max) were measured. Pdi and its components were determined during quiet breathing. No significant association was found between the activity of the disease, several serologic markers, and the inspiratory muscle dysfunction. No specific anti‐skeletal muscle antibody was found in these patients. Significant correlations were found between the degree of dyspnea and P IM (r = −0.69, P < 0.01) and Pdi max (r = −0.75, P < 0.001); however, dyspnea did not correlate with specific lung compliance. Vital capacity correlated significantly with the degree of dyspnea (r = −0.813, P < 0.001) and with Pdi max (r = 0.544, P < 0.05). No correlation was found between vital capacity and specific lung compliance. We conclude that inspiratory muscle dysfunction can be an important mechanism in the pathogenesis of the lung volume restriction and dyspnea in patients with systemic lupus erythematosus.