Open AccessExtended haplotypes of chromosome 6 in adult rheumatoid arthritis
Author(s) -
Raum D.,
Awdeh Z.,
Glass D.,
Kammer G.,
Khan M. A.,
Coblyn J. S.,
Weinblatt M.,
Holdsworth D.,
Strong L.,
Rossen R. D.,
Brewer E.,
Yunis E.,
Alper C. A.
Publication year - 1984
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780270506
Subject(s) - haplotype , linkage disequilibrium , rheumatoid arthritis , allele , genetics , medicine , arthritis , chromosome , biology , immunology , gene
In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times ( P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice ( P < 0.001) among whites with the disease‐associated chromosomes.