Open AccessTotal lymphoid irradiation therapy in refractory rheumatoid arthritis
Author(s) -
Brahn Ernest,
Helfgott Simon M.,
Belli James A.,
Anderson Ronald J.,
Reinherz Ellis L.,
Schlossman Stuart F.,
Austen K. Frank,
Trentham David E.
Publication year - 1984
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780270501
Subject(s) - medicine , rheumatoid arthritis , refractory (planetary science) , vasculitis , arthritis , adverse effect , gastroenterology , surgery , disease , physics , astrobiology
Abstract Twelve patients with refractory rheumatoid arthritis were treated with total lymphoid irradiation (TLI) to a total cumulative dose of 3,000 rads. Post‐TLI morbidity/mortality included 8 patients with xerostomia, 4 with weight loss of >10 kg, 3 with loss of 4 or more teeth, 3 with herpes zoster, 4 with bacterial infection that was fatal in 2, 3 with hypothyroidism, 1 with cutaneous vasculitis, and death from myocardial infarction in 1 patient and cardiorespiratory arrest in another. Ten of the patients were reevaluated 15–40 months (mean ± SE, 30 ± 2) after completion of TLI, and significant improvement was noted in several disease parameters including number of swollen joints, duration of morning stiffness, and 50‐foot walking time. Blood lymphopenia and a decrease in helper T cells (T4) were also noted. These data suggest that changes in immunoregulation induced by TLI can produce long‐lasting alterations in rheumatoid arthritis, although adverse effects may limit its efficacy.