Open AccessPhenotypic characterization of synovial tissue cells in situ in different types of synovitis
Author(s) -
Lindblad Staffan,
Klareskog Lars,
Hedfors Eva,
Forsum Urban,
Sundstrom Christer
Publication year - 1983
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780261104
Subject(s) - synovitis , polyarthritis , medicine , rheumatoid arthritis , synovectomy , pathology , synovial membrane , arthritis , psoriatic arthritis , immunohistochemistry , immunology
Abstract Immunohistochemical double‐staining was performed on frozen sections from synovial biopsies obtained at arthroscopy from 22 patients with different kinds of synovitis. Not only in specimens from patients with rheumatoid arthritis and seronegative chronic polyarthritis, but also in those from patients with synovitis due to psoriasis, trauma, or crystals, were seen many αLeu‐1‐positive T lymphocytes—in most cases predominantly of the αLeu‐3a‐positive T “helper” cell type—in close contact with HLA‐DR‐positive macrophages/dendritic cells. Presence of many HLA‐DR‐positive, often OKMI‐negative, and irregular sublining cells characterized all forms of chronic arthritis.