Open AccessImmunohistologic and cytochemical studies of temporal arteritis
Author(s) -
Banks Peter M.,
Cohen Marc D.,
Ginsburg William W.,
Hunder Gene G.
Publication year - 1983
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780261005
Subject(s) - histiocyte , pathogenesis , giant cell arteritis , pathology , antibody , arteritis , immunohistochemistry , immunology , monoclonal antibody , inducer , b cell , biology , medicine , vasculitis , disease , biochemistry , gene
Arteritic lesions from 14 patients with temporal arteritis were studied by cytochemical and immunohistochemical methods to identify the nature of the inflammatory cell infiltrate and to demonstrate immunoglobulin deposition. The infiltrating cells typically seen were histiocytes, giant cells, monocytes, and lymphocytes. The lymphocytes were mainly T cells and the majority of them were of the helper/inducer (Leu‐3a) T cell subset, as indicated by monoclonal antibody reactivity. Immunoglobulin deposits on the internal elastica were identified in only 6 patients and neutrophils were either very sparse or absent. These findings are consistent with the hypothesis that cell‐mediated immunity may be important in the pathogenesis of temporal arteritis.