Open AccessA new model of osteoarthritis in rabbits II. Evaluation of Anti‐Osteoarthritic Effects of Selected Antirheumatic Drugs Administered Systemically
Author(s) -
Colombo C.,
Butler M.,
Hickman L.,
Selwyn M.,
Chart J.,
Steinetz B.
Publication year - 1983
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780260911
Subject(s) - osteoarthritis , medicine , pharmacology , arthritis , gold sodium thiomalate , antirheumatic drugs , calcitonin , cartilage , triamcinolone acetonide , tamoxifen , penicillamine , rheumatoid arthritis , endocrinology , pathology , antirheumatic agents , surgery , alternative medicine , anatomy , cancer , breast cancer
A battery of drugs with antirheumatic properties was tested for effects on the progress of osteoarthritis induced by a lateral meniscectomy procedure in knee joint cartilage of rabbits. Oral administration of the potent glucocorticoids, paramethasone acetate or triamcinolone, resulted in dramatic inhibition of cartilage degeneration. Significant protection against development of osteoarthritic lesions was also observed in rabbits treated with pirprofen or CGS 5391B but not with 9 other nonsteroidal antiinflammatory drugs. A marked reduction in joint pathology was also observed in rabbits treated with tribenoside (a glucofuranoside derivative) and with tamoxifen (an anti‐estrogen). Slightly protective effects of borderline significance were observed with orgotein (a superoxide dismutase), gold sodium thiomalate, and D‐penicillamine. Chloroquine and calcitonin were without effect. Therapeutic effectiveness of drugs in this model of osteoarthritis cannot be explained on the basis of their antiinflammatory properties.