Open AccessSharing of HLA haplotype by parents of patients with systemic lupus erythematosus
Author(s) -
Schur Peter H.,
Carpenter C. B.
Publication year - 1983
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780260908
Subject(s) - haplotype , anti nuclear antibody , immunology , medicine , human leukocyte antigen , antibody , gene , genetics , biology , allele , antigen , autoantibody
Forty‐four families were studied for the relationships between HLA and systemic lupus erythematosus (SLE). Nine families had more than 1 member with SLE; haplotype sharing between SLE patients within a family was no greater than expected by chance. Fourteen of 236 relatives had antinuclear antibodies (ANA); the frequency of haplotype sharing between SLE patients and ANA‐positive relatives was no greater than expected by chance. One HLA‐A,B haplotype was shared by 7 of 35 parent pairs, a frequency (20%) significantly greater ( P = 0.004) than in 2 groups of normal controls (3.1% and 5%). These data provide evidence for HLA‐linked genes operating recessively in the expression of SLE.