Open AccessTrends in serum uric acid levels
Author(s) -
Glynn Robert J.,
Campion Edward W.,
Silbert Jeremiah E.
Publication year - 1983
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780260115
Subject(s) - uric acid , medicine , longitudinal study , population , physiology , endocrinology , environmental health , pathology
Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978. In the 1,141 men with 3 serial physical examinations, who developed no diseases and who took no drugs known to affect uric acid levels, levels rose from means below 5.5 mg/dl in 1961–1963 to means above 6.5 mg/dl in 1975–1978. The best predictor of a longitudinal increase in uric acid level was a gain in weight, but this, and other significant predictors, explained only a small portion of the increase in this population. Preliminary data available from a fourth examination indicate that the rising trend has leveled off.