Open AccessIgA nephropathy associated with seronegative spondylarthropathies
Author(s) -
Charles Jennette J.,
Ferguson Alfred L.,
Moore Michael A.,
Freeman Douglas G.
Publication year - 1982
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780250205
Subject(s) - spondylarthropathies , medicine , nephropathy , immunology , ankylosing spondylitis , glomerulonephritis , immunopathology , psoriasis , immune system , pathogenesis , spondylitis , vasculitis , dermatology , pathology , disease , kidney , endocrinology , diabetes mellitus
Three patients with a seronegative spondylarthropathy were found to have IgA nephropathy. Two patients had ankylosing spondylitis (one with psoriasis), and one had incomplete Reiter's syndrome. All three had a focal proliferative glomerulonephritis with IgA‐dominant mesangial immune deposits. One patient had a leukocytoclastic vasculitis. This association of IgA nephropathy with seronegative spondylarthropathies raises the possibility of a common or related pathogenesis. There is evidence to suggest that both diseases are mediated by genetically controlled immune responses to mucosal contact with etiologic antigens.