Open AccessTHE EFFECT OF LEAD UPON URATE NUCLEATION
Author(s) -
Tak HyonKi,
Wilcox William R.,
Cooper Sheldon M.
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780241009
Subject(s) - nucleation , chemistry , uric acid , urate oxidase , lead (geology) , biochemistry , organic chemistry , biology , paleontology
Lead urate was crystallized from solutions originally containing 0.595 m M (10 mg%) urate and 0.297 m M PbCl 2 . In the absence of lead, monosodium urate does not nucleate unless the urate concentration exceeds 80 mg%. Lead urate crystals were negatively birefringent and had a distinct x‐ray powder diffraction pattern. Crystals of monosodium urate nucleated on lead urate seed crystals when the urate concentration was 10 mg%. These studies indicate that with physiologic conditions of temperature, pH, and ionic strength, spontaneous nucleation of lead urate can be demonstrated.