Open AccessDecreased capacity to solubilize immune complexes in sera from patients with systemic lupus erythematosus
Author(s) -
Aguado M. Teresa,
Perrin L. H.,
Miescher P. A.,
Lambert P. H.
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780241001
Subject(s) - solubilization , immunology , immune system , medicine , lupus erythematosus , antibody , chemistry , biochemistry
The capacity to solubilize immune complexes formed in vitro is significantly decreased in patients with systemic lupus erythematosus (SLE). This complement function correlates significantly with serum C3 levels and inversely with the presence of circulating immune complexes. Clinically, patients with a decreased capacity to solubilize complexes show a worse evolution and an increased incidence of renal involvement. In conclusion, the impaired solubilization capacity, related to low complement activity, which is observed in patients with SLE may favor the persistence of immune complexes in tissues.