Open AccessProteoglycans from normal and degenerate cartilage of the adult human tibial plateau
Author(s) -
Santer Vivien,
White Robert J.,
Roughley Peter J.
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780240510
Subject(s) - hyaluronic acid , cartilage , keratan sulfate , proteoglycan , glycosaminoglycan , plateau (mathematics) , anatomy , chemistry , medicine , mathematics , mathematical analysis
Proteoglycans were extracted from normal and degenerate cartilage of the human tibial plateau. Both areas possessed proteoglycans of similar chemical composition, though the degenerate cartilage contained a greater proportion of molecules of lower buoyant density and enriched in keratan sulfate. There was no evidence for the changes in glycosaminoglycan synthesis that have been described for clinically osteoarthritic cartilage, or for changes in the ability to aggregate with hyaluronic acid.