Open AccessTγ lymphocytes of peripheral blood and synovial fluid in rheumatoid arthritis
Author(s) -
Mathieu Alessandro,
Mereu Maria Cristina,
Pisano Luisa
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780240505
Subject(s) - rheumatoid arthritis , synovial fluid , medicine , peripheral blood , peripheral , immunology , pathology , osteoarthritis , alternative medicine
The distribution of T γ lymphocytes in the peripheral blood of one group of rheumatoid patients and in the synovial fluid in a second group was determined. The results were compared to those found for peripheral blood (PB) lymphocytes of normal subjects and for synovial fluid lymphocytes of osteoarthrosis and meniscitis patients. Besides recording percentage and absolute number, we also used cytofluorographic analysis to determine individual capacity of PB T γ cells to bind heat‐aggregated IgG (agg‐IgG). The following results were found: 1) there is no significant difference between the percentage and absolute number of PB T γ lymphocytes of rheumatoid arthritis (RA) patients and those of controls, 2) individual RA PB T γ cells had a greater number and/or avidity of Fc receptor for IgG than those cells of controls, and 3) the percentage of RA T γ lymphocytes in synovial fluid, revealed by IgG‐EA ox rosetting, is significantly lower than that found in control patients. The factors that may determine a similar lymphocyte picture in RA are discussed.