Open AccessEffect of high‐dose methylprednisolone infusion on polymorphonuclear leukocyte function in patients with systemic lupus erythematosus
Author(s) -
Daniel Perez H.,
Kimberley Robert P.,
Kaplan Howard B.,
Edelson Henry,
Inman Robert D.,
Goldstein Ira M.,
Mellon Andrew W.
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780240502
Subject(s) - methylprednisolone , medicine , lupus erythematosus , drug , polymorphonuclear leukocyte , systemic lupus erythematosus , immunology , pharmacology , chemistry , in vitro , biochemistry , disease , antibody
We have studied the effect of high‐dose (1 gm) methylprednisolone infusion on polymorphonuclear leukocyte (PMN) function in 11 patients with active systemic lupus erythematosus (SLE). The only alteration of polymorphonuclear leukocyte function produced consistently by methylprednisolone was decreased adherence to plastic surfaces when tested 2 hours after infusion. This steroid‐induced abnormality, however, was transient. Cells obtained from patients 24 hours after a single dose of drug exhibited normal adhesiveness. These results indicate that single, large doses of methylprednisolone do not produce long‐lasting abnormalities of PMN function in patients with lupus.