Open AccessBINDING SITES FOR IMMUNE COMPONENTS IN HUMAN CHOROID PLEXUS
Author(s) -
Peress Nancy S.,
Roxburgh Vivian A.,
Gelfand Michael C.
Publication year - 1981
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780240312
Subject(s) - choroid plexus , antibody , avidity , complement system , immunology , immune system , central nervous system , receptor , medicine , immune complex , complement receptor , immunoglobulin g , pathology , biology , endocrinology
In immunologically mediated disorders such as systemic lupus erythematosus and experimental serum sickness, immunoglobulin and complement may be localized in the choroid plexus. This report demonstrates the presence of binding activity for the Fc fragment of IgG in 34 of 36 samples of human choroid plexus. We suggest that the number, distribution, and avidity of these Ig receptors may modulate the occurrence and/or severity of central nervous system symptoms in patients with immunologically mediated systemic diseases.