Open AccessAssociation of hla‐drw4 with rheumatoid arthritis in black and white patients
Author(s) -
Karr Robert W.,
Rodey Glenn E.,
Lee Tsung,
Schwartz Benjamin D.
Publication year - 1980
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780231102
Subject(s) - rheumatoid arthritis , medicine , white (mutation) , negroid , human leukocyte antigen , arthritis , immunology , race (biology) , antigen , epidemiology , biology , genetics , gene , botany
The HLA‐A, B, C, and DR antigens were typed in 35 black and 35 white Americans with rheumatoid arthritis. The frequency of HLA‐DRw4 was increased in both the black and white patient groups compared to the race‐matched control groups. DRw4 was found in 45.7% of the black patients compared to 14.3% of the black controls (corrected P value <0.035) and DRw4 was found in 71.4% of the white patients compared to 40.0% of the white controls (corrected P value <0.035). These data indicate that immunogenetic factors related to DRw4 are important in the development of rheumatoid arthritis in American blacks as well as whites.