Open AccessBone histomorphometry in pacet's disease quantitative and dynamic analysis of pagetic and nonpagetic bone tissue
Author(s) -
Meunier Pierre J.,
Coindre Jean M.,
Edouard Claude M.,
Arlot Monique E.
Publication year - 1980
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780231005
Subject(s) - osteosclerosis , bone histomorphometry , pathology , bone pathology , bone remodeling , bone tissue , medicine , bone disease , trabecular bone , osteoporosis
Transiliac bone biopsies from 136 untreated pagetic patients, taken from both pagetic (72 cases) and nonpagetic bone (64 cases), were quantitatively analyzed. Tetracycline double labeling analysis demonstrated that osteosclerosis of pagetic bone results from an overproduction of woven bone by the osteoblasts. Increased bone cell populations appeared as the consequence of an increased birthrate of the basic multicellular units. In 45% of patients biopsied in nonpagetic bone, there were prints of an increased bone remodeling attributed to a hyperparathyroidism secondary to the high calcium demand of pagetic bones.