Open AccessHeterogeneity of the spontaneously expanded and mitogen‐induced generation of suppressor cell function of t cells on b cells in systemic lupus erythematosus
Author(s) -
RuizArguelles Alejandro,
AlarcónSegovia Donato,
Llorente Luis,
Del GuidiceKnipping JOSéa
Publication year - 1980
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780230907
Subject(s) - suppressor , peripheral blood mononuclear cell , autoantibody , immunology , systemic disease , medicine , lupus erythematosus , connective tissue disease , systemic lupus erythematosus , b cell , autoimmune disease , disease , immunopathology , biology , in vitro , antibody , genetics , cancer
Eighty percent of 31 untreated patients with systemic lupus erythematosus (SLE) and abnormalities in their spontaneously expanded and/or Con‐A‐induced suppressor cell function, but the association of defects detected with both systems was only 68%. Loss of spontaneous suppression related positively to disease activity (r = 0.641) and the number of T γ cells (r = 0.624) whereas Con‐A‐induced suppression correlated negatively with disease activity (r = ‐0.456) and the number of T γ cells (r = ‐0.089). Incubation of mononuclear cells from SLE patients in antiribonucleoprotein IgG caused further loss of suppression in some, but not all, instances. The suppressor cell dysfunction found in SLE may result from diverse mechanisms, including a basic defect in the generation of suppressor cells and the abrogation of suppressor function by autoantibodies.