Open AccessCorrelative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus
Author(s) -
Moutsopoulos Haralampos M.,
Klippel John H.,
Pavlidis Nicholas,
Wolf Robert O.,
Sweet James B.,
Steinberg Alfred D.,
Chu Fred C.,
Tarpley Thomas M.
Publication year - 1980
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780230107
Subject(s) - medicine , sicca syndrome , serology , autoantibody , systemic disease , pathology , biopsy , lupus erythematosus , connective tissue disease , dermatology , immunopathology , antibody , autoimmune disease , immunology , disease
We prospectively evaluated 24 patients with systemic lupus erythematosus for clinical, histologic, and serologic evidence of sicca syndrome. Abnormalities suggestive of sicca syndrome in patients with systemic lupus were identified by parotid scan (58%), questionnaire (54%), labial biopsy (50%), Schirmer's test (21%), and parotid flow rate (13%). An increased frequency of autoantibodies to gamma globulin and cellular antigen SS‐A was detected in lupus patients with histologic changes on labial biopsy. The serologic findings are similar to those of patients with sicca syndrome alone with the exception of the reduced incidence of anti‐SS‐B in patients with systemic lupus.