Open AccessLymphocytotoxic antibodies in systemic lupus erythematosus and clinically related diseases
Author(s) -
Schocket Alan L.,
Kohler Peter F.
Publication year - 1979
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780221003
Subject(s) - medicine , immunology , lupus erythematosus , systemic lupus erythematosus , antibody , mixed connective tissue disease , connective tissue disease , vasculitis , connective tissue , systemic disease , incidence (geometry) , discoid lupus erythematosus , disease , autoimmune disease , pathology , immunopathology , physics , optics
Sera from patients with systemic lupus erythematosus (SLE) and clinically related diseases were examined for cold‐reactive lymphocytotoxic antibodies (LCA). The incidence of LCA was significantly increased in SLE (93%), discoid lupus (50%), and “lupuslike” syndromes associated with congenital complement deficiencies (63%) as compared to normal controls (3%) and patients with drug‐induced lupus (11%), mixed connective tissue disease (MCTD) (17%), and necrotizing vasculitis (19%). The diagnostic and pathogenetic implications of these differences are discussed.