Open AccessDevelopment and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization
Author(s) -
Palmoski Marshall,
Perricone Elaine,
Brandt Kenneth D.
Publication year - 1979
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780220511
Subject(s) - proteoglycan , cartilage , articular cartilage , osteoarthritis , chemistry , medicine , anatomy , pathology , alternative medicine
Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.