Open AccessDetection of low avidity anti‐dna antibodies in systemic lupus erythematosus
Author(s) -
Riley Richard L.,
Mcgrath Hugh,
Taylor Ronald P.
Publication year - 1979
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780220303
Subject(s) - avidity , antibody , polyethylene glycol , immunology , lupus erythematosus , dna , medicine , peg ratio , virology , chemistry , biochemistry , finance , economics
Abstract The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.