Open AccessLymphopenia In Systemic Lupus Erythematosus
Author(s) -
Rivero Santiago J.,
DíazJouanen Efraín,
AlarcónSegovia Donato
Publication year - 1978
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780210302
Subject(s) - polymyositis , medicine , mixed connective tissue disease , connective tissue disease , connective tissue , lupus erythematosus , systemic lupus erythematosus , immunology , systemic disease , lymphocyte , disease , rheumatology , pathology , immunopathology , autoimmune disease , antibody
One hundred fifty‐eight patients with active, untreated systemic lupus erythematosus (SLE) were studied from the time of diagnosis. Lymphopenia was present in 75%, and another 18% of these patients developed lymphopenia subsequent to disease reactivation. Lymphopenia of less than 1500 cells/m̈l occurred more frequently than any of the preliminary criteria for the classification of SLE, and it was the most prevalent initial laboratory abnormality. Lymphocyte counts were significantly lower in lupus than in the other connective tissue diseases except mixed connective tissue disease and polymyositis.