Open AccessNormal distribution of acetylation phenotypes in systemic lupus erythematosus
Author(s) -
Vansant Johnathan,
Woosley Raymond L.,
John J. Thomas,
Sergent John S.
Publication year - 1978
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780210203
Subject(s) - dapsone , phenotype , medicine , systemic lupus erythematosus , acetylation , immunology , lupus erythematosus , population , gastroenterology , biology , disease , antibody , genetics , environmental health , gene
Abstract Previous reports have indicated that idiopathic systemic lupus erythematosus (SLE), like drug‐induced lupus, is more frequent in “slow” hepatic acetylators. Using dapsone acetylation rate to determine phenotypes, we found that of the 18 SLE patients studied, 9 were fast acetylators, 8 were slow, and 1 was indeterminate. This result (53% fast) is similar to acetylator phenotypes in our normal controls (50% fast) and in the population at large (52%).