Open AccessIncreased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis
Author(s) -
McMichael Andrew J.,
Sasazuki Takehiko,
McDevitt Hugh O.,
Payne Rose O.
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200501
Subject(s) - rheumatoid arthritis , linkage disequilibrium , medicine , human leukocyte antigen , immunology , locus (genetics) , allele , antigen , genetics , biology , haplotype , gene
Thirty‐nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA‐Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.