Immune complexes and complement catabolism in ankylosing spondylitis | Zendy

Gabay R. | Zendy; Zubler R. H. | Zendy; Nydegger U. E. | Zendy; Lambert P. H. | Zendy

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Immune complexes and complement catabolism in ankylosing spondylitis

Author(s) -

Gabay R.,

Zubler R. H.,

Nydegger U. E.,

Lambert P. H.

Publication year - 1977

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780200402

Subject(s) - ankylosing spondylitis , rheumatoid arthritis , immune system , immunology , catabolism , medicine , immune complex , spondylitis , gastroenterology , metabolism

In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125 I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( > 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.

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