Open AccessConnective tissue activation
Author(s) -
Castor C. W.,
Ritchie J. C.,
Scott M. E.,
Whitney S. L.
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200316
Subject(s) - connective tissue , hyaluronic acid , mediator , platelet , thymidine , dna synthesis , chemistry , peptide , microbiology and biotechnology , biochemistry , dna , biology , immunology , pathology , medicine , anatomy
This report describes a small basic protein found in human platelets which stimulates hyaluronic acid formation, glucose uptake, and lactate formation in several types of human connective tissue cells. In addition, it stimulates the incorporation of [ 3 H] methyl thymidine into DNA in human synovial cell cultures. This platelet factor (connective tissue activating peptide‐III, CTAP‐III) clearly differs from CTAP‐I, found in human lymphocytes, and may play a role as a mediator of the inflammatory process.