Open AccessAntibody levels to enteric bacteria in juvenile rheumatoid arthritis
Author(s) -
GutowskaGrzegorczyk Grazyna,
Baum John
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200303
Subject(s) - antibody , immunology , juvenile rheumatoid arthritis , shigella , antigen , titer , antibody titer , immunoglobulin a , arthritis , medicine , biology , microbiology and biotechnology , immunoglobulin g , bacteria , salmonella , genetics
In order to determine the immunologic status and possible susceptibility to bacterial infection in children with juvenile rheumatoid arthritis (JRA), titers of hemagglutinating antibodies to E coli 055, E coli 086, common antigen, and Shigella polyvalent antigen were measured. Immunoglobulin G was the predominant antibody. IgA antibodies were found in higher titers in children with JRA. No significant differences were found between children with JRA and matched controls. These data show that children with JRA do not have any deficit in antibody production to specific bacterial antigens, and any increased appearance of infection in these children is more probably due to deficiencies in cellular factors.