Open AccessD‐penicillamine in the treatment of rheumatoid arthritis
Author(s) -
Tsang Ian K.,
Patterson Caroline A.,
Stein Howard B.,
Robinson Harold S.,
Ford Denys K.
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200205
Subject(s) - penicillamine , rheumatoid arthritis , medicine , gold salts , surgery , drug , gastroenterology , pharmacology
Forty‐four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D‐penicillamine on a so‐called go‐slow, go‐low regime. Seventeen patients tolerated the drug and had a 3−13 month follow‐up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patients because of toxic side effects.