Open AccessAvidity of antibodies in sle
Author(s) -
Leon Shalom A.,
Green Anthony,
Ehrlich George E.,
Poland Marcia,
Shapiro Bernard
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200104
Subject(s) - avidity , lupus nephritis , nephritis , antibody , medicine , immunology , kidney disease , kidney , autoimmune disease , gastroenterology , disease
The avidity of antibodies to DNA in the sera of 8 patients with SLE was determined by saturation analysis and Scatchard plots. Five of the patients had severe lupus nephritis; the other 3 had relatively mild or no kidney disease. The Scatchard plots revealed components with high relative avidity in the patients with severe nephritis (K values 4.4–10.4 x 10 5 M −1 for nDNA), compared with the patients who had mild or no kidney disease (K values 0.3–1.8 x 10 5 M −1 for nDNA). Avidity measurements may be helpful in the evaluation and treatment of patients with SLE.