Open AccessSystemic lupus erythematosus associated with klinefelter's syndrome
Author(s) -
Stern R.,
Fishman J.,
Brusman H.,
Kunkel H. G.
Publication year - 1977
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780200103
Subject(s) - medicine , klinefelter syndrome , endocrinology , estrogen , lupus erythematosus , urinary system , stimulation , immunology , antibody
Studies in estrogen metabolism were carried out in 2 males with systemic lupus erythematosus (SLE) who also had Klinefelter's syndrome. Although these studies revealed elevated levels of urinary estrogens in 1 patient, abnormalities of estradiol metabolism suggesting persistent estrogen stimulation were detected in both. This report notes an association between SLE and Klinefelter's syndrome and suggests that chronic estrogenic stimulation may be significant in the development of SLE in these 2 patients.