Open AccessCellular hypersensitivity in rheumatoid arthritis, ankylosing spondylitis, and anterior nongranulomatous uveitis
Author(s) -
Thonar E. JM. A.,
Sweet M. B. E.
Publication year - 1976
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780190305
Subject(s) - ankylosing spondylitis , uvea , medicine , uveitis , rheumatoid arthritis , immunology , antigen , synovial membrane , spondylitis , arthritis , pathology , eye disease , ophthalmology
The humoral and cellular responses to normal human ocular and joint tissue antigens were studied in rheumatoid arthritis, ankylosing spondylitis, and anterior non‐granulomatous uveitis. No free‐circulating autoantibodies could be detected by hemagglutination, immunodiffusion, and immunofluorescence. Uvea‐retina, synovial membrane, and articular cartilage antigen preparations inhibited the migration of leukocytes from patients with rheumatoid arthritis. In ankylosing spondylitis inhibition could be induced only by synovial membrane antigens. Patients with anterior nongranulomatous uveitis were hypersensitive to uvea‐retina antigens alone.