Open AccessEffect of aspirin on liver tests in patients with ra or sle and in normal volunteers
Author(s) -
Seaman William E.,
Plotz Paul H.
Publication year - 1976
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780190205
Subject(s) - aspirin , medicine , gastroenterology , volunteer , creatinine , liver function tests , agronomy , biology
Aspirin was given to 20 patients with RA, 16 patients with SLE, and 3 normal volunteers. Four of the RA patients, 7 of the SLE patients, and 1 normal volunteer developed abnormal liver tests during the study. The abnormalities (elevated transaminases) were most frequent and of rapid onset in patients with clinically active SLE. Increases in BUN and creatinine related to aspirin were observed in several subjects. In a retrospective survey of 80 patients with SLE, aspirin appeared responsible for two‐thirds of episodes of liver test abnormalities in 19 patients.