Open AccessImmunoglobulin deposits in skin in systemic lupus erythematosus
Author(s) -
Wierzchowiecki M. O.,
Quismorio F. P.,
Friou G. J.
Publication year - 1975
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780180115
Subject(s) - antibody , anti nuclear antibody , basement membrane , medicine , immunology , lupus erythematosus , immunoglobulin g , glomerular basement membrane , chemistry , pathology , kidney , glomerulonephritis , autoantibody
Abstract Immunoglobulin deposits in the dermal‐epidermal junction of clinically normal skin from patients with SLE were eluted by acid buffer. The eluates contained antinuclear and antibasement membrane antibody activities. The anti‐BM antibody reacted with skin and esophageal but not glomerular basement membrane. Enzymatic studies indicated that the antibody reacted with carbohydrate moeities in the basement membrane. The anti‐BM antibody was not present in corresponding sera of SLE patients.