Open AccessAryl sulfatase activities in normal and pathologic human articular cartilage
Author(s) -
Schwartz Edith R.,
Ogle Roy C.,
Thompson Roby C.
Publication year - 1974
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780170417
Subject(s) - keratan sulfate , sulfatase , medicine , cartilage , chondroitin sulfate , osteoarthritis , articular cartilage , chemistry , endocrinology , biochemistry , enzyme , anatomy , pathology , glycosaminoglycan , alternative medicine
Aryl sulfatase A and B activities were measured in articular cartilage of patients with osteoarthritis, chondromalacia, avascular necrosis, and femoral neck fractures. Although the activities of both enzymes were higher in the tissue from individuals with degenerative joint disease, the most significant finding was the substantial increase in the B:A ratio in these tissues. It is suggested that whereas cerebroside sulfate is the substrate for aryl sulfatase A, either chondroitin sulfate or keratan sulfate is the physiologic substrate for aryl sulfatase B.