Open AccessHeterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus description of a cytoplasmic nonribosomal antigen
Author(s) -
Mattioli Martha,
Reichlin Morris
Publication year - 1974
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780170413
Subject(s) - antigen , anti nuclear antibody , rna , nucleic acid , cytoplasm , antibody , immunology , connective tissue , lupus erythematosus , ribonucleoprotein , biology , medicine , autoantibody , pathology , biochemistry , gene
A soluble cytoplasmic RNA protein antigen (La) is described, which precipitates with sera of patients with systemic lupus erythematosus and a small number of patients who lack antinuclear factors but who have various connective tissue symptoms. Antibodies to the cytoplasmic RNA protein are almost invariably (8 of 9 cases) accompanied by antibodies to a non‐nucleic acid cytoplasmic antigen, Ro. Description of this antigen enlarges the spectrum of nucleic acid antigens reactive with the sera of patients with systemic lupus erythematosus.